1068441-76-8

Upstream product

• 868846-65-5 N-allyl-N-[2-(1-tolylsulfonyl-1H-indol-3-yl)-ethyl]-formamide 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 1156537-61-9 11-tosyl-5,6,11,11b-tetrahydro-3H-indolizino[8,7-b]indole 
• 1397694-08-4 dimethyl 2-(allyl(2-(2-((E)-5-methoxy-5-oxopent-1-enyl)-1-tosyl-1H-indol-3-yl)ethyl)amino)maleate 
• 1068441-77-9 dimethyl 7-allyl-3-tosyl-6,7,10,13-tetrahydro-5H-7,13-diazacyclodeca[a]indene-8,9-dicarboxylate 
• 1397693-94-5 dimethyl (E)-2-(9-tosyl-1-vinyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)but-2-enedioate 
• 1397693-93-4 dimethyl 2-(allyl(2-(2-((E)-6-methoxy-4-(methoxycarbonyl)-5,6-dioxohex-1-enyl)-1-tosyl-1H-indol-3-yl)ethyl)amino)maleate 

Relevant academic research and scientific papers

Novel chemistry of β-carbolines. Expedient synthesis of polycyclic scaffolds

Functionalization of β-carbolines is a challenge as numerous natural alkaloids with different biological activities present this heterocycle. The RCM is used herein with allyl-, vinyl-, ethynyl-, and propargyl-β-carbolines to generate additionally fused h

Novel domino reactions in β-carbolines with triple bonded dienophiles

Vinylpyrrolo-[2,1-a]-β-carbolines 1 give different products upon reaction with dienophiles. With dimethyl acetylenedicarboxylate (DMAD), a novel domino process takes place, involving Michael attack and rearrangement, affording complex polycycles like 3, 4, and 5. Diels-Alder cycloadditions are favored in the presence of Lewis acids and are the only reactions with dimethyl maleate. When 3-butyn-2-one is used as dienophile, a Stevens rearrangement is observed giving product 9.