106848-50-4Relevant academic research and scientific papers
Bi- and Tricyclic Twelve-ring Azacrowns by Stepwise Annelation
Buoeen, Solfrid,Dale, Johannes
, p. 141 - 144 (2007/10/02)
Starting from unprotected 1,4,7,10-tetraazacyclododecane, a second ring can be annelated in a direct reaction with triethylglycol ditosylate.The main bicyclic product with the bridge between N1 and N4 (12-membered ring), is accompanied by an isomer (10percent) presumed to have the bridge between N1 and N7 (15-membered ring).There is no further reaction when Na2CO3 (in acetonitrile) is used as the base.With Cs2CO3 a tricyclic product, bridged exclusively between N1 and N4 and between N7 and N10, is formed.In its complex with NaI only two of the rings are used, as shown by 13C NMR.Analogous bicyclic products were obtained from 1-oxa-4,7,10-triazacyclododecane.
