1068604-40-9Relevant academic research and scientific papers
A model study on installation of (Z)-γ-methylglutaconic acid onto the 3-aminophenol core of divergolide A
Zhao, Guanglian,Wu, Jinlong,Dai, Wei-Min
, p. 4779 - 4787 (2015)
Divergolide A and its four congeners, divergolide E-H, possess an amido-substituted hydroquinone core, which is biosynthetically transformed from an aromatic starter unit, 3-amino-5-hydroxybenzoic acid (AHBA). The macrocyclic ring of divergolide A and F i
Toward a total synthesis of divergolide A; Synthesis of the amido hydro- Quinone core and the C10-C15 fragment
Zhao, Guanglian,Wu, Jinlong,Dai, Wei-Min
, p. 2845 - 2849 (2013/02/22)
A ring-closing metathesis (RCM) approach was envisioned for installing the E double bond at the C9 and C10 positions of divergolide A, isolated from a mangrove endophyte. Accordingly, the C10-C15 diene diol fragment and the amido hydroquinone core with the requisite functionalities and stereochemistry have been synthesized by using the norephedrine-based syn-selective glycolate aldol and the anti-selective aldol reactions, respectively. CuI-catalyzed amidation was employed to access the anilide intermediate, which was further transformed into the amido hydroquinone core. Copyright
PROCESS FOR PREPARING TRIAZOLONES
-
Page/Page column 20, (2009/01/20)
The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones
Non-nucleoside reverse transcriptase inhibitors
-
Page/Page column 26-27, (2008/12/08)
Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
