1068607-42-0Relevant articles and documents
Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
Koltun, Dmitry O.,Parkhill, Eric Q.,Vasilevich, Natalya I.,Glushkov, Andrei I.,Zilbershtein, Timur M.,Ivanov, Alexei V.,Cole, Andrew G.,Henderson, Ian,Zautke, Nathan A.,Brunn, Sandra A.,Mollova, Nevena,Leung, Kwan,Chisholm, Jeffrey W.,Zablocki, Jeff
scheme or table, p. 2048 - 2052 (2009/11/30)
We identified a series of structurally novel SCD (Δ9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the central bicyclic scaffold has proven key to our potency optimization effort. The most potent analog (8
