1068635-64-2Relevant academic research and scientific papers
Formal total synthesis of benzylpedamide: The right half of (+)-pederin
Liu, Degang,Xue, Jijun,Xie, Zhixiang,Wei, Liping,Zhang, Xianshu,Li, Ying
scheme or table, p. 1526 - 1528 (2009/04/07)
The right half of (+)-pederin was synthesized through a convenient and efficient asymmetric synthesis in 14 steps with 8.3% overall yield. The key step was an iodine-induced heterocy-clization to construct the pyran ring. The chiral centers were constructed separately via asymmetric allylation, substrate-controlled diastereoselective reactions, and Sharpless asymmetric dihydroxy-lation.
