1068660-01-4

Upstream product

• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 88945-41-9 N-(Cyanmethyl)formimidsaeure-methylester 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 1285456-49-6 3-(triacetyl-β-D-ribofuranosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1285456-58-7 3-(β-D-ribofuranosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1260651-33-9 5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1285456-79-2 3-(tetraacetyl-β-D-glucopyranosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1285456-85-0 3-(β-D-glucopyranosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1285456-89-4 3-(triacetyl-α-L-rhamnosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 
• 1285456-96-3 3-(α-L-rhamnosyl)-5-phenyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Synthesis of fluorinated purine and 1-deazapurine glycosides as potential inhibitors of adenosine deaminase

The synthesis of 2- and 6-trifluoromethylated purines and 1-deazapurines was performed by formal [3 + 3]-cyclization reactions of 5-aminoimidazoles with a set of trifluoromethyl-substituted 1,3-CCC- and 1,3-CNC-dielectrophiles. The corresponding fluorinated nucleosides were synthesized by glycosylation of 9-unsubstituted purines and 1-deazapurines with peracetylated β-ribose, β-glucose, and rhamnose and subsequent deprotection. These scaffolds can be considered as potential inhibitors of adenosine deaminase (ADA) and inosine monophosphate dehydrogenase (IMPDH) enzymes.

A convenient one-pot synthesis of 7-trifluoromethyl-substituted imidazo [4,5-b] pyridines

This communication describes a practical and facile one-pot approach for the Synthesis of 7-trifluoromethyl-substituted imi-dazo[4,5-6]pyridines by the reaction of in situ generated 5-ami-noimidazole and a 1,3-CCC-biselectrophile.