106871-91-4

Upstream product

• 94662-49-4 3-(methylthio)thieno<3,4-d>isothiazole 1,1-dioxide 
• 106871-89-0 1-[[3-(3-aminopropoxy)phenyl]carbonyl]piperidine 
• 59337-79-0 thieno(3,4-d)-1,2-thiazol-3(2H)-one 1,1-dioxide 
• 106871-88-9 1-<3-<3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propoxy>benzoyl>piperidine 
• 106871-87-8 4-(aminosulfonyl)-3-thiophenecarbonyl chloride 
• 59337-86-9 4-(aminosulfonyl)-3-thiophenecarboxylic acid 
• 94662-48-3 thieno[3,4-d]isothiazole-3(2H)-thione 1,1-dioxide 
• 15504-60-6 1-(3-hydroxybenzoyl)piperidine 
• 106871-90-3 4-(aminosulfonyl)-N-<3-<3-(1-piperidinecarbonyl)phenoxy>propyl>-3-thiophenecarboxamide 

Relevant academic research and scientific papers

Syntheses and Gastric Acid Antisecretory Properties of the H2-Receptor Antagonist N-propyl>thienoisothiazol-3-amine 1,1-Dioxide and Related Derivatives

The synthesis and gastric acid antisecretory properties of several N-substituted thienoisothiazol-3-amine 1,1-dioxides and analogues are described.Two of the more potent compounds, N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6a) and N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6b), showed greater potencies as H2-receptor antagonist (in vitro) than ranitidine.They also had potent gastric acid antisecretory activities in vivo, inhibiting basal acid secretion in the rat (6a, 6b), histamine-stimulated acid secretion in the dog (6a, 6b), and food-stimulated acid secretion in the dog (6a).These were selected for further pharmacological evaluation.