106872-27-9

Basic information

• Product Name: 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER
• Synonyms: 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER
• CAS NO: 106872-27-9
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.36
• Mol File: 106872-27-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER(106872-27-9)
• EPA Substance Registry System: 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER(106872-27-9)

Safety Data

• Hazardous Substances Data: 106872-27-9(Hazardous Substances Data)

Usage

General Description

2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER is a chemical compound with the molecular formula C16H18N2O3. It is an ester derivative of 2-CBZ-amino-4-phenylbut-2-enoic acid and is commonly used as an intermediate in the synthesis of pharmaceutical compounds. 2-CBZ-AMINO-4-PHENYLBUT-2-ENOIC ACID METHYL ESTER is a white to off-white crystalline powder that is soluble in organic solvents. It is primarily used as a reagent in organic synthesis and as a building block for the preparation of various pharmaceutical products. This chemical has applications in the pharmaceutical industry and is commonly used in the production of drugs and other active pharmaceutical ingredients.

Upstream product

• 64356-76-9 N-benzyloxycarbonyl α-chloro glycine methyl ester 
• 103-64-0 bromostyrene 

Relevant articles and documents

SYNTHESIS OF α-AMINO ACIDS WITH β,γ-UNSATURATED SIDE CHAINS

α-Amino acids with allenyl, vinyl and acetylenic side chains can be synthesized using non-enolate based strategies.The ester enolate-Claisen rearrangement applied to propargylic esters of N-protected α-amino acids is of limited utility since only poor yields of allenic product are obtained with the N-Boc glycine esters, the system which give the most reproducible results.However, α-allenyl-α-amino acids that are fully functionalized on the α-carbon are available through the agency of 4-allenyl-2-phenyloxazolones 4 ( obtained from propargyl esters of N-benzoyl protected amino acids via cyclization and Claisen rearrangement ) provided that Meerwein's reagent is used to facilitate hydrolysis of the benzamide function in 5.A variety of α-substituted glycinates, including those with α-vinyl and α-acetylenic functions, can be prepared using a two step sequence involving condensation of the cationic glycine synthon 22 with various organomagnesium reagents, followed by hydrolysis.