1069-52-9Relevant articles and documents
Process for the production of 2-alkyl- or cycloalkyl-4-methyl-6-hydroxypyrimidines
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, (2008/06/13)
Production of 2-alkyl- or cycloalkyl-4-methyl-6-hydroxypyrimidines by first neutralizing an alkyl imidate ester hydrochloride with a base in the presence of a water-immiscible solvent for the alkyl imidate ester to be freed thereby; condensing the alkyl imidate ester with diketene to form an oxazinone intermediate, which is then reacted in organic solution with gaseous ammonia and recovering the desired substituted 6-hydroxypyrimidine.