1069018-66-1Relevant academic research and scientific papers
A convenient negishi protocol for the synthesis of glycosylated oligo(ethynylene)s
Hoheisel, Tobias N.,Frauenrath, Holger
, p. 4525 - 4528 (2008)
(Chemical Equation Presented) A convenient and efficient sp-sp carbon heterocoupling protocol based on the Negishi reaction was developed, in which the required zinc diacetylide was generated from 1,4-bis(trimethylsilyl) butadiyne in situ and reacted with a bromoacetylene in apolar solvent mixtures. The method has been applied to the synthesis of unsymmetric glycosylated and symmetric diglycosylated oligo(ethynylene)s up to the octa(ethynylene).
