1069018-77-4Relevant articles and documents
Seleninate in place of phosphate: Irreversible inhibition of protein tyrosine phosphatases
Abdo, Mohannad,Liu, Sijiu,Zhou, Bo,Walls, Chad D.,Wu, Li,Knapp, Spencer,Zhang, Zhong-Yin
, p. 13196 - 13197 (2008)
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization. Copyright