1069040-52-3

Basic information

• Product Name: (1R,2S,5S,3R,4R)-1-benzyloxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane
• Synonyms: (1R,2S,5S,3R,4R)-1-benzyloxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane
• CAS NO: 1069040-52-3
• Molecular Weight: 571.789
• Mol File: 1069040-52-3.mol

Chemical Properties

• CAS DataBase Reference: (1R,2S,5S,3R,4R)-1-benzyloxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5S,3R,4R)-1-benzyloxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane(1069040-52-3)
• EPA Substance Registry System: (1R,2S,5S,3R,4R)-1-benzyloxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane(1069040-52-3)

Safety Data

• Hazardous Substances Data: 1069040-52-3(Hazardous Substances Data)

Upstream product

• 1069040-48-7 (1R,2S,5S,3R,4R)-1-azidocarbonyl-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1069040-54-5 (1R,2S,5S,3R,4R)-1-amino-4-[(tert-butyldiphenylsilyloxy)methyl]-2,3-O-isopropylidene-2,3-dihydroxybicyclo[3.1.0]hexane 

Relevant articles and documents

Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands

(Chemical Equation Presented) We have developed an approach toward enantiomerically pure (S)-methanocarba ribonucleosides based on several functional group transformations on a sensitive bicyclo[3.1.0]-hexane system. D-Ribose was transformed into methanocarba alcohol 3 followed by conversion of the OH group to a nitrile with inversion of configuration at C4. The nitrile group was subsequently reduced in two stages to the 5′-hydroxymethyl group. An ester group appended to a tertiary carbon (Cl) was transformed to an amino group as a nucleobase precursor.