1069085-45-5

Basic information

• Product Name: 1-Methyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole
• Synonyms: 1-Methyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole
• CAS NO: 1069085-45-5
• Molecular Formula: C5H7F3N2
• Molecular Weight: 152
• Mol File: 1069085-45-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole(1069085-45-5)
• EPA Substance Registry System: 1-Methyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole(1069085-45-5)

Safety Data

• Hazardous Substances Data: 1069085-45-5(Hazardous Substances Data)

Usage

Compound Type

Heterocyclic organic compound.

Structure

Five-membered ring containing one nitrogen atom.

Applications

Synthesis of pharmaceuticals and agrochemicals, building block in the synthesis of new drugs, and as a reagent in chemical reactions.

Potential

Studied for its biological activities and possible therapeutic potential in certain medical treatments.

Upstream product

• 76-05-1 trifluoroacetic acid 
• 109-81-9 N-methyl-ethane-1,2-diamine 

Relevant articles and documents

A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates

A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.