106910-74-1Relevant academic research and scientific papers
Simple preparation method of 4 (3H)-quinazolinone derivative
-
Paragraph 0012, (2018/02/04)
The invention provides a simple preparation method of a 4 (3H)-quinazolinone derivative, the 4 (3H)-quinazolinone derivative can be synthesized in one step in a mixed solvent from anthranilamide and an aldehyde as raw materials under the catalysis effects of an ion catalyst, due to the use of the mixed solvent, the 4 (3H)-quinazolinone derivative can be postprocessed only by washing with ethanol and drying, postprocessing steps are simplified, the purity of the product is improved, and meanwhile time is saved.
Cyclisation of Schiff Bases containing Amide or Hydroxamic Acid Groups to 1,2-Dihydroquinazolin-4-ones; Thermal Decomposition Reaction of the 1,2-Dihydroquinazolin-4-ones
Christie, Robert M.,Moss, Stephen
, p. 2779 - 2784 (2007/10/02)
2-Hydroxynaphthalene-1-carbaldehyde reacts with o-aminobenzamide in methanol to produce the Schiff base (1a) whereas reaction with 2-aminobenzohydroxamic acid leads directly to the dihydrohydroxyquinazolinone (2b).The Schiff base (1b), an intermediate in the formation of (2b), can be isolated (in an impure form) by quenching the reaction with water.When refluxed in dichlorobenzene the dihydrohydroxyquinazolinone (2b) decomposes in part by carbon-carbon bond fission to give 3-hydroxyquinazoline-4(3H)-one (5) and 2-naphthol and to a lesser extent by dehydration leading to the quinazolinone (4).The dihydroquinazolinone (2a) is readily prepared by cyclisation of the Schiff base (1a) and decomposes thermally to give quinazolin-4(3H)-one (9) and 2-naphthol.A mechanism for the carbon-carbon bond cleavage observed in the thermal decompositions is proposed.
