1069261-00-2Relevant academic research and scientific papers
Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors
Susnik, Marko P.,Schnuerch, Michael,Mihovilovic, Marko D.,Mereiter, Kurt,Stanetty, Peter
experimental part, p. 423 - 430 (2010/05/01)
A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6- pyrimidinyl)-ethanones, obtained via Weinreb's methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution.
