106942-12-5Relevant academic research and scientific papers
Synthesis of maculalactone A and derivatives for environmental fate tracking studies
Bader, Samuel L.,Luescher, Michael U.,Gademann, Karl
, p. 199 - 206 (2015/02/19)
Maculalactone A (1) constitutes a promising antifouling agent, inhibiting the formation of biofilms in marine and freshwater systems. In this study, we developed a new route, based on a late-stage formation of the butenolide core, leading to the total synthesis of maculalactone A (three steps, overall yield of 45%) and delivering material on a gram scale. In addition, analogues of the title compound were assayed concerning their biological activity, utilizing Artemia franciscana and Thamnocephalus platyurus. The most active analogue was functionalized with a rhodamine B fluorophore and was utilized in an in vivo staining experiment in Artemia salina. Two different tissues were found to accumulate this maculalactone A derivative. This journal is
Pigments of Fungi. XV An Efficient, Unambiguous Route to Unsymmetrically Substituted Dibenzyl Acyloins and their Use in the Synthesis of Fungus Pigments of the Pulvinone and Grevillin Types
Gill, Melvyn,Kiefel, Milton J.,Lally, Deborah A.,Ten, Abilio
, p. 1497 - 1518 (2007/10/02)
Dibenzyl acyloins including those bearing unsymetrically disposed aryl residues are assembled in high yield by reaction between the O-trimethylsilyl ethers of arylacetaldehyde cyanohydrins and benzyl Grignard reagents.These acyloins are deprotonated with
ADDITION OF ORGANOMAGNESIUM REAGENTS TO CYANOHYDRIN-O-SILYL ETHERS: AN EFFICIENT AND FLEXIBLE SYNTHESIS OF UNSYMMETRICALLY SUBSTITUTED ACYLOINS
Gill, Melvyn,Kiefel, Milton J.,Lally, Deborah A.
, p. 1933 - 1934 (2007/10/02)
Acyloins are prepared in high yields via reaction between Grignard reagents and O-trimethylsilyl ethers of aldehyde cyanohydrins: the method is particularly useful for the preparation of discrete acyloins in which the substituens are unsymmetrically dispo
