106956-32-5

Basic information

• Product Name: HUMAN ONCOSTATIN M
• Synonyms: ONCOSTATIN M, HUMAN;ONCOSTATIN M, HUMAN, RECOMBINANT;OSM;RHOSM;REC ONCOSTATIN M (HUMAN);REC OSM (HUMAN);RECOMBINANT HUMAN ONCOSTATIN M;HUMAN OSM
• CAS NO: 106956-32-5
• Molecular Formula: Unspecified
• Molecular Weight: 0
• EINECS: 200-835-2
• Mol File: 106956-32-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: HUMAN ONCOSTATIN M(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN ONCOSTATIN M(106956-32-5)
• EPA Substance Registry System: HUMAN ONCOSTATIN M(106956-32-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37
• WGK Germany: 3
• Hazardous Substances Data: 106956-32-5(Hazardous Substances Data)

Usage

Uses

Human oncostatin-M has been used to stimulate bovine full-depth cartilage explants. It has also been used to culture embryonic stem cells in standard minimum essential medium-α.

General Description

Oncostatin M (OSM) is produced by activated T cells, monocytes and Kaposi′s sarcoma cells. OSM shares several structural and functional characteristics with leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and ciliary neurotrophic factor (CNTF).

Biochem/physiol Actions

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. It can exert both stimulatory and inhibitory effects on cell proliferation. OSM stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi′s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release [e.g. interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony-stimulating factor (G-CSF)] from endothelial cells.