106962-17-8

Upstream product

• 106962-15-6 2-((S)-4-Acetylamino-3-oxo-isoxazolidin-2-yl)-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 

Downstream Products

• 106962-32-7 5-Oxo-2-[(S)-3-oxo-4-(2-thiophen-2-yl-acetylamino)-isoxazolidin-2-yl]-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 119144-12-6 2-[(S)-4-((R)-2-Amino-2-phenyl-acetylamino)-3-oxo-isoxazolidin-2-yl]-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 106945-38-4 2-{(S)-4-[2-Hydroxy-2-(4-hydroxy-phenyl)-acetylamino]-3-oxo-isoxazolidin-2-yl}-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 128797-39-7 benzhydryl 2-<(4S)-4-<(2,2-dichloro)vinylthioacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate 
• 114359-11-4 benzhydryl 2-<(4S)-4-<(Z)-2-(chloro)vinylthioacetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate 
• 106945-47-5 5-Oxo-2-[(S)-3-oxo-4-(2-oxo-propionylamino)-isoxazolidin-2-yl]-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 106962-34-9 benzhydryl 2-<(4S)-4-cyanoacetylamino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate 
• 106962-55-4 2-[(S)-4-(2-Benzyloxycarbonylamino-acetylamino)-3-oxo-isoxazolidin-2-yl]-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 106944-86-9 2-((S)-4-Butyrylamino-3-oxo-isoxazolidin-2-yl)-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 106962-51-0 benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate 
• 106944-93-8 5-Oxo-2-((S)-3-oxo-4-phenylacetylamino-isoxazolidin-2-yl)-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 106944-84-7 2-((S)-4-Formylamino-3-oxo-isoxazolidin-2-yl)-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester 
• 119144-14-8 4-phenylacetyl 4-ALA pivaloyloxymethylester 
• 105629-08-1 Na salt of N-butyryl-4-amino-lactivinic acid 

Relevant academic research and scientific papers

CHEMISTRY OF A NEW ANTIBIOTIC: LACTIVICIN

A novel antibiotic, lactivicin (LTV), was isolated from the culture filtrates of two bacterial strains by various types of chromatography.LTV exists in aqueous solution as an equilibrium mixture of two epimers in a ratio of about 1:1.The chemical structure of LTV (C10H12N2O7) was determined to be 2-(4S-acetylamino-3-oxo-2-isoxazolidinyl)-5-oxo-tetrahydrofuran-2-carboxylic acid.The absolute configuration at the C-6 position was elucidated from the CD spectral data and X-ray crystallographic analysis of 4-amino-lactivinic acid obtained by the iminoether method.This compound is useful as a starting material for chemical modification.LTV showed antibacterial activity against Gram-positive and negative bacteria, susceptibility to β-lactamases, and affinity for penicillin-binding proteins.We therefore concluded that LTV is a novel skeleton antibiotic having β-lactam-like activities.

STRUCTURE OF LACTIVICIN, AN ANTIBIOTIC HAVING A NEW NUCLEUS AND SIMILAR BIOLOGICAL ACTIVITIES TO β-LACTAM ANTIBIOTICS

The structure of a new antibiotic, lactivicin, was determined to be -2-(4-acetylamino-3-oxo-2-isoxazolidinyl)-5-oxo-tetrahydrofuran-2-carboxylic acid.