1069984-11-7

Basic information

• Product Name: 2-phenyl-1-azulenyl p-tolyl sulfone
• Synonyms: 2-phenyl-1-azulenyl p-tolyl sulfone
• CAS NO: 1069984-11-7
• Molecular Weight: 358.461
• Mol File: 1069984-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1-azulenyl p-tolyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1-azulenyl p-tolyl sulfone(1069984-11-7)
• EPA Substance Registry System: 2-phenyl-1-azulenyl p-tolyl sulfone(1069984-11-7)

Safety Data

• Hazardous Substances Data: 1069984-11-7(Hazardous Substances Data)

Upstream product

• 1069983-99-8 2-iodo-1-azulenyl p-tolyl sulfone 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 1069984-00-4 1-(p-tolylsulfonyl)azulene-2-boronic acid 

Downstream Products

• 19227-07-7 2-phenylazulene 

Relevant articles and documents

A new efficient route to 2-substituted azulenes based on sulfonyl group directed lithiation

(Chemical Equation Presented) Directed lithiation of p-tolyl 1-azulenyl sulfone (1) at the 2-position of the azulenyl group was achieved by using lithium 2,2,6,6-tetramethylpiperidide (LTMP). The azulenyllithium thus generated could be efficiently trapped with various electrophiles to form 2-substituted derivatives 2 in moderate to good yields. p-Tolyl 2-trimethylsilyl-1-azulenyl sulfone (2a) was transformed into cyclic sulfone derivative 3a through the directed lithiation in the p-tolyl group and subsequent intramolecular ring closure at the 8-position. 2-(Phenylsulfanyl)-1-azulenyl p-tolyl sulfone (2b) suffered from desulfonylation to form 2-phenylsulfanylazulene (4). The Suzuki coupling reaction of 2-iodo-1-azulenyl p-tolyl sulfone (2d) with arylboronic acids followed by desulfonylation efficiently gave 2-arylazulenes 10.