107023-40-5

Upstream product

• 120427-74-9 methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate 
• 2935-90-2 Methyl 3-mercaptopropionate 
• 108082-09-3 ((+/-)-trans)-Methyl 3-<2-(8-phenyloctyl)phenyl>oxiranecarboxylate 
• 96964-45-3 2-(8-phenyloctyl) benzaldehyde 

Downstream Products

• 108116-15-0 (2R,3S)-3-(2-Carboxy-ethylsulfanyl)-2-hydroxy-3-[2-(8-phenyl-octyl)-phenyl]-propionic acid 
• 107023-41-6 pobilukast 
• 120427-74-9 methyl-α-hydroxy-β-[(2-(methoxycarbonyl)ethyl)thio]-2-(8-phenyloctyl)benzenepropanoate 

Relevant academic research and scientific papers

Process and intermediate for the preparation of 2-hydroxy-3-sulfido-3-phenyl propanoic acids

STR1 This invention relates to intermediate compounds of formula (VI), wherein: R1 is (L)a --(CH2)b --(T)c --B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH=CH, C C, or CH2 ; B is H, C1-4 alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl unsubstituted or monosubstituted by Br, Cl, CF3, C1-4 alkoxy, C1-4 alkyl, methylthio or trifluoromethylthio; R2 and A are independently selected from H, CF3, C1-4 alkyl, C1-4 alkoxy, F, Cl, Br, I, OH, NO2 or NH2 ; or, when R1 and A are H, R2 is (L)a --(CH2)b --(T)c --B wherein a, b, c, L, T and B are as defined above; and M is H, Li, Na, K, NH4 or an organic ammonium cation, and their use in a process for preparing leukotriene antagonists.

ESTER PRODRUGS

This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, pharmaceutical compositions containing such compounds, and methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

This invention relates to alkanoic acid compounds having phenyl and sulfinyl or sulfonyl substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. The invention also relates to the use of such compound for treatment of diseases in which leukotrienes are a factor.

Leukotriene antagonists

This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

THIOPHENYL ALKANOIC ACIDS USEFUL AS LEUKOTRIENE ANTAGONISTS

This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.