1070240-58-2Relevant academic research and scientific papers
Asymmetric Mukaiyama aldol reaction of nonactivated ketones catalyzed by allo-threonine-derived oxazaborolidinone
Adachi, Shinya,Harada, Toshiro
supporting information; experimental part, p. 4991 - 5001 (2009/05/31)
(Chemical Equation Presented) Asymmetric Mukaiyama aldol reaction of nonactivated ketones is realized for the first time by using an oxazaborolidinone catalyst derived from O-benzoyl-N-tosyl-allo-threonine. By employing a dimethylsilyl ketene S,O-acetal as a nucleophile, a variety of acetophenone derivatives afford the corresponding tertiary β-hydroxy carbonyl compounds with high enantioselectivity up to 98% ee.
