107035-10-9

Basic information

• Product Name: Brn 6064992
• Synonyms: (+)-2,3,4,4A,5,9B-Hexahydro-5-phenyl-1-propyl-1H-indeno(1,2-B)pyridine;1H-Indeno(1,2-B)pyridine, 2,3,4,4A,5,9B-hexahydro-5-phenyl-1-propyl-, (+)-;Brn 6064992
• CAS NO: 107035-10-9
• Molecular Formula: C₂₁H₂₅N
• Molecular Weight: 291.4299
• Mol File: 107035-10-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Brn 6064992(CAS DataBase Reference)
• NIST Chemistry Reference: Brn 6064992(107035-10-9)
• EPA Substance Registry System: Brn 6064992(107035-10-9)

Safety Data

• Hazardous Substances Data: 107035-10-9(Hazardous Substances Data)

Upstream product

• 88823-34-1 (+/-)-4aR,5S,9bR-1-n-propyl-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridine 
• 88687-33-6 (4aR,5R,9bR)-5-Phenyl-1-propyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridine; hydrochloride 

Downstream Products

• 107035-09-6 (-)-4aS,5R,9bR-1-n-propyl-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno<1,2-b>pyridine 

Relevant articles and documents

Resolution, Absolute Stereochemistry, and Enantioselective Activity of Nomifensine and Hexahydro-1H-indenopyridines

Nomifensine and three selected compounds from the series of H4a,H5-trans,H4a,H9b-cis-2,3,4,4a,5,9b-hexahydro-1H-indenopyridines have been resolved into their enantiomers.All compounds exhibit pronounced enantioselective activity with respect to their inhibition of tetrabenazine-induced ptosis and potentiation of yohimbine toxicity.Nomifensine exhibits the same preference for one enantiomer with respect to dopamine and norepinephrine reuptake, whereas in the indenopyridine series in vitro experiments do not discriminate between the optical antipodes.The absolute stereochemistry of the pharmacologically active enantiomers in both series was determined by X-ray analyses and comparative CD spectra.For biological activity the diphenylmethane is an essential structure feature in both series.Its absolute configuration proved to be 4S for nomifensine and 5S for indenopyridines.The similar pharmacological profile of the two chemical entities is therefor reflected in an identical configuration of this pharmacologically important molecular part.