107036-57-7 Usage
General Description
5-Bromo-2',3'-dideoxycytidine is a synthetic nucleoside analogue that has been studied for its potential use in the treatment of viral infections and cancer. It is a derivative of cytidine, a nucleoside found in DNA and RNA, and contains a bromine atom at the 5 position of the pyrimidine ring. This modification inhibits the enzyme DNA polymerase, preventing the replication of viral DNA or cancerous cells. The compound has shown promise in preclinical studies as an antiviral and anticancer agent, and it is being investigated as a potential treatment for HIV, hepatitis B and C, and various types of cancer. Additionally, it has been studied for its potential to enhance the efficacy of traditional chemotherapeutic drugs when used in combination. Overall, 5-Bromo-2',3'-dideoxycytidine holds potential as a therapeutic agent for a range of medical conditions, and its development is ongoing.
Check Digit Verification of cas no
The CAS Registry Mumber 107036-57-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,3 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 107036-57:
(8*1)+(7*0)+(6*7)+(5*0)+(4*3)+(3*6)+(2*5)+(1*7)=97
97 % 10 = 7
So 107036-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H12BrN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h3,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m0/s1
107036-57-7Relevant articles and documents
Determining DNA sequences by mass spectrometry
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, (2008/06/13)
This invention relates to the methods, apparatus, reagents and mixtures of reagents for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine, guanine, cytosine or thymine) is a component of the terminal nucleotide. In particular, the present invention relates to identifying the individual nucleotides by the mass of stable nuclide markers contained within either the dideoxynucleotides, the DNA primer, or the deoxynucleotide added to the primer. This invention is particularly useful in identifying specific DNA sequences in very small quantities in biological products produced by fermentation or other genetic engineering techniques. The invention is therefore useful in evaluating safety and other health concerns related to the presence of DNA in products resulting from genetic engineering techniques.
Potent Anti-AIDS Drugs. 2',3'-Dideoxycytidine Analogues
Kim, Chong-Ho,Marquez, Victor E.,Broder, Samuel,Mitsuya, Hiroaki,Driscoll, John S.
, p. 862 - 866 (2007/10/02)
5-Substituted 2',3'-dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV-III/LAV (HIV) virus, the causative agent of acquired immunodefi
