1070503-92-2 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole, 6-bromo-4-(phenylmethoxy)is used as a reactant in the synthesis of IDO inhibitors, such as exiguamine A and B. These inhibitors are of significant interest in the pharmaceutical industry due to their potential applications in the treatment of various diseases, including cancer and inflammatory disorders. The indole-based structure of 1H-Indole, 6-bromo-4-(phenylmethoxy)- allows for the development of novel and effective inhibitors targeting the IDO enzyme, which plays a crucial role in immune response and has been implicated in the pathogenesis of several diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1070503-92-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,0,5,0 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1070503-92:
(9*1)+(8*0)+(7*7)+(6*0)+(5*5)+(4*0)+(3*3)+(2*9)+(1*2)=112
112 % 10 = 2
So 1070503-92-2 is a valid CAS Registry Number.
1070503-92-2Relevant academic research and scientific papers
Total synthesis of exiguamines A and B inspired by catecholamine chemistry
Sofiyev, Vladimir,Lumb, Jean-Philip,Volgraf, Matthew,Trauner, Dirk
, p. 4999 - 5005 (2012/06/04)
The evolution of a total synthesis of the exiguamines, two structurally unusual natural products that are highly active inhibitors of indolamine-2,3-dioxygenase (IDO), is described. The ultimately successful strategy involves advanced cross-coupling methodology and features a potentially biosynthetic tautomerization/electrocyclization cascade reaction that forms two heterocycles and installs a quaternary ammonium ion in a single synthetic operation. Copyright
