107059-85-8Relevant academic research and scientific papers
Visible-Light-Induced Oxidation of Diazenyl-Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams
Jin, Weiwei,Liu, Chenjiang,Wang, Bin,Wang, Yanhong,Xia, Yu,Zhang, Tao,Zhang, Yonghong
supporting information, (2022/05/17)
A visible-light-induced oxidation of diazenyl-protected tetrahydroisoquinolines and isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was carried out with Eosin Y-Na2 as an organic photocatalyst and molecular oxygen as an oxidant, and the desired functionalized N-aryldiazenyl-lactams were obtained under mild and transition metal-free conditions. The utility of this method is showcased by the gram-scale synthesis and deprotection of the N-aryldiazenyl-lactam product. (Figure presented.).
