1070672-49-9

Basic information

• Product Name: 2-(4-nitrophenyl)-2-phenylacetaldehyde
• Synonyms: 2-(4-nitrophenyl)-2-phenylacetaldehyde
• CAS NO: 1070672-49-9
• Molecular Weight: 241.246
• Mol File: 1070672-49-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-2-phenylacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-2-phenylacetaldehyde(1070672-49-9)
• EPA Substance Registry System: 2-(4-nitrophenyl)-2-phenylacetaldehyde(1070672-49-9)

Safety Data

• Hazardous Substances Data: 1070672-49-9(Hazardous Substances Data)

Upstream product

• 4336-57-6 trans-2-(4-nitrophenyl)-3-phenyloxirane 
• 4336-57-6 2-(4-nitrophenyl)-3-phenyl oxirane 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Copper(II) tetrafluroborate-promoted Meinwald rearrangement reactions of epoxides

Epoxides undergo a highly efficient Meinwald rearrangement in the presence of catalytic quantities of copper(II) tetrafluoroborate to give carbonyl compounds in high yields and with excellent selectivity. The low toxicity and ease of handling of this reagent make it an attractive alternative to the more corrosive or costly Lewis acids frequently employed.

Catalytic, regioselective, and green methods for rearrangement of 1,2-diaryl epoxides to carbonyl compounds employing metallic triflates, Br?nsted-acidic ionic liquids (ILs), and IL/microwave; Experimental and computational substituent effect study on aryl versus hydrogen migration

The Lewis-acid catalyzed rearrangement of parent trans-stilbene oxide 1 was studied with M(OTf)3/DCM and M(OTf)3/[BMIM][BF 4] (M = Bi, Al, Ga, Sc, and Yb; [BMIM] = butylmethylimidazolium) and Zn(NTf2)2, and with Bi(OTf)3/[BMIM][X] (X = NTf2, OTf, PF6, and BF4), employing 5 mol% of catalyst. Selective formation of 2,2-dipheylacetaldehyde 2 (phenyl migration product) was observed in all cases, with Bi(OTf)3 proving most efficient. The rearrangement of 1 was also effected in [BMIM][X] (X = NTf 2, OTf, PF6, and BF4) without an added catalyst under microwave MW irradiation, and X = PF6 gave the highest yield and selectivity. Efficient and selective rearrangement of 1-2 was also observed with 0.1-0.3 equiv. of [BMIM(SO3H)][OTf] in DCM and in [BMIM][X]. A substituent effect study was performed with a series of singly substituted 1,2-diphenyl oxiranes (with X = OMe, Me, F, CN, and NO2) with 5 mol% Bi(OTf)3 in DCM and in [BMIM][NTf2]. Notable formation of ketones was observed with the NO2 and CN derivatives. Competing formation of ketones was also observed in [BMIM][PF6] under MW and under Br?nsted acid catalysis with [BMIM(SO3H)][OTf] in DCM and in [BMIM][NTf2]. The aryl versus H migration was studied computationally by DFT and MP2 methods and by including solvation effects (IEFPCM).