1070731-12-2Relevant academic research and scientific papers
A General Palladium–Phosphine Complex To Explore Aryl Tosylates in the N-Arylation of Amines: Scope and Limitations
Choy, Pui Ying,Chung, Kin Ho,Yang, Qingjing,So, Chau Ming,Sun, Raymond Wai-Yin,Kwong, Fuk Yee
supporting information, p. 2465 - 2474 (2018/09/10)
The scope and limitations of the monoselective N-arylation of various amines by using aryl and hetaryl tosylates are presented. The air-stable and easily accessible Pd(OAc)2/CM-phos {CM-phos=2-[2-(dicyclohexylphosphino)phenyl]-1-methyl-1H-indole}catalyst system was able to deal with a wide range of aryl tosylate substrates as well as amine nucleophiles, including primary and secondary cyclic/acyclic aliphatic amines and anilines. NH-Bearing heterocycles such as indole, carbazole, pyrrole, 10-phenothiazine, and 10-phenoxazine were shown to be feasible coupling partners under this catalytic system. The described reaction conditions tolerate a wide range of functional groups and allow an array of aromatic amines as well as unsymmetrical amine products to be easily accessed from the various phenolic derivatives. Interestingly, this catalyst system even offers the opportunity to perform the reaction in water medium. We also report the intermolecular coupling of optically active α-central chiral amines with aryl tosylates without erosion of the enantiomeric purity.
Novel robust benzimidazolylidene palladium complexes: Synthesis, structure, and catalytic applications in amination of chloroarenes
Fang, Weiwei,Jiang, Jian,Xu, Yong,Zhou, Juefei,Tu, Tao
, p. 673 - 679 (2013/07/27)
A series of novel pyridine stabilized PdeNHC complexes were developed, which revealed high activities and broad substrates tolerance in the amination of various (hetero)-aryl chlorides. Besides various secondary amines, a wide range of primary anilines and aliphatic amines were also well tolerated. The results highlight us a new strategy to increase catalyst activity in the future catalyst design by alternating the σ-donor property and flexibility of NHC ligands.
A highly efficient precatalyst for amination of aryl chlorides: Synthesis, structure and application of a robust acenaphthoimidazolylidene palladium complex
Tu, Tao,Fang, Weiwei,Jiang, Jian
supporting information; experimental part, p. 12358 - 12360 (2011/12/15)
A robust palladium NHC complex was synthesized and exhibits exceptional activity and selectivity as a precatalyst in the amination of aryl chlorides and tolerates a wide range of substrates at low catalyst loadings.
Palladium-catalyzed amination of aryl mesylates
So, Chau Ming,Zhou, Zhongyuan,Lau, Chak Po,Kwong, Fuk Yee
supporting information; experimental part, p. 6402 - 6406 (2009/03/11)
(Chemical Equation Presented) Aminated adventures: The new phosphine ligand L in combination with a Pd(OAc)2 precursor provides the first palladium-catalyzed amination of unactivated aryl mesylates. This catalyst system can be applied in an aqueous reaction medium without detrimental effect.
