1070733-63-9

Basic information

• Product Name: 2-(5''-methylthien-2''-yl)-4-(3'-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine
• CAS NO: 1070733-63-9
• Molecular Weight: 351.493
• Mol File: 1070733-63-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5''-methylthien-2''-yl)-4-(3'-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5''-methylthien-2''-yl)-4-(3'-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine(1070733-63-9)
• EPA Substance Registry System: 2-(5''-methylthien-2''-yl)-4-(3'-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine(1070733-63-9)

Safety Data

• Hazardous Substances Data: 1070733-63-9(Hazardous Substances Data)

Upstream product

• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 121-71-1 3-Hydroxyacetophenone 
• 137-07-5 2-amino-benzenethiol 

Relevant articles and documents

Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines

Solid-phase synthesis of a parallel library of 3′-hydroxy-2,3-dihydrobenzothiazepines has been carried out through [4+3] annulation of α,β-unsaturated ketones with aminothiophenol, using Wang resin as solid support. The synthesized compounds were evaluated for their potential as antibacterial, tumor inhibitors as well as acetyl- and butyrylcholinesterase inhibitors. None of the compounds showed any significant antibacterial activity. However, quite a few compounds showed significant potential as crown gall tumor inhibitors. These results reflect a strong exploratory potential in search of new benzothiazepines as source of anticancer agents. The results of the inhibition of cholinesterase revealed that benzothiazepines have a greater potential as butyrylcholinesterase inhibitors as compared to acetylcholinesterase. Moreover, the substitution of hydroxy group at C-3 in ring A led to increased activity when compared to unsubstituted- and 2′-OH substituted benzothiazepines.