1070753-99-9

Upstream product

• 1070753-95-5 (Z)-2-(toluene-4-sulfinyl)-1-trifluoromethylvinylamine 
• 934-72-5 Methyl p-tolyl sulfoxide 
• 1070753-94-4 1,1,1-trifluoro-3-(toluene-4-sulfinyl)propan-2-one 
• 1070753-97-7 2,2,2-trifluoro-1-(toluene-4-sulfinylmethyl)ethylamine 

Downstream Products

• 1070753-39-7 2-amino-4,6-dichloro-N-(2,2,2-trifluoro-1-p-tolylsulfanylmethylethyl)-benzenesulfonamide 

Relevant academic research and scientific papers

THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING

The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.