Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1070772-12-1

4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1070772-12-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1070772-12-1 Structure

  • Basic information

    1. Product Name: 4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
    2. Synonyms: 4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
    3. CAS NO:1070772-12-1
    4. Molecular Formula:
    5. Molecular Weight: 426.478
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1070772-12-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one(1070772-12-1)
    11. EPA Substance Registry System: 4-[[3-(4-pyrimidin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one(1070772-12-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1070772-12-1(Hazardous Substances Data)

1070772-12-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1070772-12-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,0,7,7 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1070772-12:
(9*1)+(8*0)+(7*7)+(6*0)+(5*7)+(4*7)+(3*2)+(2*1)+(1*2)=131
131 % 10 = 1
So 1070772-12-1 is a valid CAS Registry Number.

1070772-12-1Downstream Products

1070772-12-1Relevant articles and documents

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one: A novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1

Menear, Keith A.,Adcock, Claire,Boulter, Robert,Cockcroft, Xiao-Ling,Copsey, Louise,Cranston, Aaron,Dillon, Krystyna J.,Drzewiecki, Jan,Garman, Sheila,Gomez, Sylvie,Javaid, Hashim,Kerrigan, Frank,Knights, Charlotte,Lau, Alan,Loh Jr., Vincent M.,Matthews, Ian T. W.,Moore, Stephen,O'Connor, Mark J.,Smith, Graeme C. M.,Martin, Niall M. B.

experimental part, p. 6581 - 6591 (2009/10/17)

Poly(ADP-ribose) polymerase activation is an immediate cellular response to metabolic-, chemical-, or ionizing radiation-induced DNA damage and represents a new target for cancer therapy. In this article, we disclose a novel series of substituted 4-benzyl-2H-phthalazin-1-ones that possess high inhibitory enzyme and cellular potency for both PARP-1 and PARP-2. Optimized compounds from the series also demonstrate good pharmacokinetic profiles, oral bioavailability, and activity in vivo in an SW620 colorectal cancer xenograft model. 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl] -2H-phthalazin-1-one (KU-0059436, AZD2281) 47 is a single digit nanomolar inhibitor of both PARP-1 and PARP-2 that shows standalone activity against BRCA1-deficient breast cancer cell lines. Compound 47 is currently undergoing clinical development for the treatment of BRCA1- and BRCA2-defective cancers.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1070772-12-1