1070872-68-2

Upstream product

• 1070872-67-1 (-)-(2R,3R,4R)-4-allyloxy-5,5,5-trifluoro-2,3-dihydroxy-4-phenyl-pentanoic acid dimethylamide 
• 1070872-64-8 (-)-(2S,4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenyl-ethyl)-2-phenyl-[1,3]dioxolane-4-carboxylic acid dimethylamide 
• 1070872-63-7 (-)-(4R,5R)-5-((R)-1-allyloxy-2,2,2-trifluoro-1-phenylethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide 

Downstream Products

• 1070872-70-6 (2R)-2-allyloxy-3,3,3-trifluoro-2-phenyl-propan-1-ol 
• 1187092-92-7 (R)-N-(2-allyloxy-2-phenyl-3,3,3-trifluoropropyl)benzylamine 

Relevant academic research and scientific papers

Enantiopure quaternary α-trifluoromethyl-α-alkoxyaldehydes from L-tartaric acid derived ketoamides

(Chemical Equation Presented) The diastereoselective nucleophilic trifluoromethylation of a range of ketoamides derived from L-tartaric acid has been studied. TMSCF3 in the presence of a catalytic amount of K 2CO3 in DMF has been identified as the conditions leading to the highest diastereoselectivities. A sequential one-pot reaction trifluoromethylation-etherification of the trifluoromethylcarbinol has been developed. Only one further one-pot reaction, ketal hydrolysis-oxidative cleavage, led to the final α-trifluoromethylated α-alkoxy-aldehydes. This procedure was applied to the preparation of a series of enantiopure aryl, heteroaryl, and alkyl α-trifluoromethyl-α-alkoxyaldehydes.