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1070877-57-4

C22H21ClO5 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1070877-57-4 Structure

  • Basic information

    1. Product Name: C22H21ClO5
    2. Synonyms:
    3. CAS NO:1070877-57-4
    4. Molecular Formula:
    5. Molecular Weight: 400.859
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1070877-57-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C22H21ClO5(CAS DataBase Reference)
    10. NIST Chemistry Reference: C22H21ClO5(1070877-57-4)
    11. EPA Substance Registry System: C22H21ClO5(1070877-57-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1070877-57-4(Hazardous Substances Data)

1070877-57-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1070877-57-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,0,8,7 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1070877-57:
(9*1)+(8*0)+(7*7)+(6*0)+(5*8)+(4*7)+(3*7)+(2*5)+(1*7)=164
164 % 10 = 4
So 1070877-57-4 is a valid CAS Registry Number.

1070877-57-4Relevant articles and documents

Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

Yamamoto, Takashi,Niwa, Seiji,Tokumasu, Munetaka,Onishi, Tomoyuki,Ohno, Seiji,Hagihara, Masako,Koganei, Hajime,Fujita, Shin-Ichi,Takeda, Tomoko,Saitou, Yuki,Iwayama, Satoshi,Takahara, Akira,Iwata, Seinosuke,Shoji, Masataka

scheme or table, p. 3639 - 3642 (2012/07/17)

A structure-activity relationship study of 6-unsubstituted-1,4- dihydropyridine and 2,6-unsubstituted-1,4-dihydropyridine derivatives was conducted in an attempt to discover N-type calcium channel blockers that were highly selective over L-type calcium channel blockers. Among the tested compounds, (+)-4-(3,5-dichloro-4-methoxy-phenyl)-1,4-dihydro-pyridine-3,5- dicarboxylic acid 3-cinnamyl ester was found to be an effective and selective N-type calcium channel blocker with oral analgesic potential.

The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

Yamamoto, Takashi,Niwa, Seiji,Ohno, Seiji,Tokumasu, Munetaka,Masuzawa, Yoko,Nakanishi, Chika,Nakajo, Akira,Onishi, Tomoyuki,Koganei, Hajime,Fujita, Shin-ichi,Takeda, Tomoko,Kito, Morikazu,Ono, Yukitsugu,Saitou, Yuki,Takahara, Akira,Iwata, Seinosuke,Shoji, Masataka

body text, p. 4813 - 4816 (2009/06/06)

In order to find an injectable and selective N-type calcium channel blocker, we have performed the structure-activity relationship (SAR) study on the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylate derivative APJ2708 (2), which is a derivative of Cilnidipine and has L/N-type calcium channel dual inhibitory activities. As a consequence of the optimization, 6-dimethylacetal derivative 7 was found to have an effective inhibitory activity against N-type calcium channels with more than 170-fold lower activity for L-type channel compared to that of APJ2708.

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