107089-77-0

Usage

Uses

Used in Ophthalmology:
3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide is used as a diuretic agent in ophthalmology for the treatment of glaucoma. It functions by reducing the production of fluid in the eye, which in turn lowers intraocular pressure, alleviating symptoms and preventing further damage to the optic nerve.
Used in High Altitude Medicine:
In high altitude medicine, 3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide is utilized to prevent and treat acute mountain sickness. Its diuretic effect helps decrease the buildup of bodily fluids, thus mitigating symptoms such as headache, tiredness, and shortness of breath experienced at high altitudes.
Used in Nephrology:
3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide is employed in nephrology for the treatment of certain kidney disorders. Its ability to regulate fluid balance can assist in managing conditions that affect the kidneys' ability to filter waste and excess fluids from the blood.
Used in Neurology:
In neurology, 3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide is used for the prevention of seizures in specific conditions. Its mechanism of action can help stabilize the electrical activity in the brain, reducing the likelihood of seizure episodes.

InChI:InChI=1/C9H9ClN2O2S/c1-2-12-7-5-3-4-6-8(7)15(13,14)11-9(12)10/h3-6H,2H2,1H3

Upstream product

• 102308-74-7 4-ethyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide 
• 147192-77-6 N-[3-[3-(piperidinomethyl)phenoxy]propyl]-4'-methoxybenzylamine 
• 103-69-5 N-ethyl-N-phenylamine 

Downstream Products

• 107089-80-5 3-hydrazino-4-ethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide 
• 1280555-51-2 (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione 
• 1280555-46-5 (S)-[{N-3-[3-fluoro-4-(4-(4-ethyl-1,1-dioxo-1,4-dihydro-1,2,4-benzothiadiazin-3-yl)piperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]acetamide 
• 1280555-33-0 C₂₃H₂₆FN₅O₄S₂ 
• 1280555-27-2 C₂₃H₂₆FN₅O₅S 
• 1280555-64-7 C₃₆H₃₄ClFN₆O₆S 
• 1280555-57-8 C₂₃H₂₇FN₆O₄S 
• 107089-86-1 2-(4-Ethyl-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 107089-83-8 3-(3,5-Dimethyl-pyrazol-1-yl)-4-ethyl-4H-benzo[1,2,4]thiadiazine 1,1-dioxide 

Relevant academic research and scientific papers

Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1,1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium int

Benzothiadiazine derivatives

A benzothiadiazine derivative, hydrate thereof and acid addition salt thereof, the derivative being represented by the general formula (I) STR1 wherein X is methylene or a nitrogen atom substituted with a lower alkyl, Y and Z are each methylene or carbonyl, A is phenylene or phenylene substituted with methoxycarbonyl, R4 is lower alkylene or lower alkenylene, R1 is a hydrogen atom, acetoxyacetyl, cyclohexylmethyl or benzyl wherein the benzene ring may be substituted with lower alkoxyl, halogen atom, nitro, lower alkyl, methylenedioxy or hydroxyl, R2 is lower alkyl or phenyl, and R3 is a hydrogen atom, halogen atom or lower alkoxyl with the exception of the case where X, Y and Z are each methylene, A is unsubstituted phenylene, R4 is lower alkylene and R1 is a hydrogen atom; and a peptic ulcer treating agent containing as an effective component the above derivative, hydrate thereof or acid addition salt thereof.

Synthesis and Biological Activity of 3-Pyrazolyl-4-substituted-2H-1,2,4-benzothiadiazine 1,1-Dioxides

3-Chloro derivatives (IIIa-c) obtained from 2H-1,2,4-benzothiadiazine-3(4H)-one 1,1-dioxides (IIa-c) by treatment with PCl5, on reaction with hydrazine hydrate furnish 3-hydrazino-2H-1,2,4-benzothiadiazine 1,1-dioxides (IVa-c).Condensation of IVa-c with a