1070896-59-1

Basic information

• Product Name: 4-Piperidinone,3-fluoro,HCl
• Synonyms: 4-Piperidinone,3-fluoro,HCl;3-Fluoro-4-piperidinone hydrochloride;3-Fluoro-4-piperidinone,,HCl;3-Fluoro-4-piperidone Hydrochloride;4-piperidinone, 3-fluoro-, hydrochloride;3-Fluoropiperidin-4-one hydrochloride;3-FLUORO-4-PIPERIDONE HCL
• CAS NO: 1070896-59-1
• Molecular Formula: C₅H₈FNO*ClH
• Molecular Weight: 153.5824632
• Mol File: 1070896-59-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 214.5 °C at 760 mmHg
• Flash Point: 83.5 °C
• Appearance: /
• CAS DataBase Reference: 4-Piperidinone,3-fluoro,HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone,3-fluoro,HCl(1070896-59-1)
• EPA Substance Registry System: 4-Piperidinone,3-fluoro,HCl(1070896-59-1)

Safety Data

• Hazardous Substances Data: 1070896-59-1(Hazardous Substances Data)

Usage

Uses

3-Fluoro-4-piperidinone, HCl

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 211108-48-4 tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate 
• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 

Downstream Products

• 845256-59-9 benzyl 3-fluoro-4-oxopiperidine-1-carboxylate 
• 1274806-00-6 1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-one 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER

The present invention includes novel compound and methods of treating a disease or disorder by antagonizing Bcl-2 family proteins, particularly compounds of Formula (I) or pharmaceutically acceptable salt thereof, as well as methods of treating a disease,