1070906-67-0Relevant academic research and scientific papers
Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists
Jin, Jian,Budzik, Brian,Wang, Yonghui,Shi, Dongchuan,Wang, Feng,Xie, Haibo,Wan, Zehong,Zhu, Chongye,Foley, James J.,Webb, Edward F.,Berlanga, Manuela,Burman, Miriam,Sarau, Henry M.,Morrow, Dwight M.,Moore, Michael L.,Rivero, Ralph A.,Palovich, Michael,Salmon, Michael,Belmonte, Kristen E.,Lainé, Dramane I.
, p. 5915 - 5918 (2008)
A series of novel biphenyl piperazines was discovered as highly potent muscarinic acetylcholine receptor antagonists via high throughput screening and subsequent optimization. Compound 5c with respective 500- and 20-fold subtype selectivity for M3/s
