1071-75-6

Usage

Uses

Used in Pharmaceutical Industry:
S-PropylthiuroniuM BroMide is used as a radioprotective agent for its potential to protect cells and tissues from the harmful effects of x-rays. This application is particularly relevant in the context of radiation therapy for cancer patients, where it may help to minimize damage to healthy cells while maximizing the effectiveness of the treatment.
Used in Research and Development:
In addition to its potential pharmaceutical applications, S-PropylthiuroniuM BroMide may also be utilized in research and development settings to study the effects of radiation on biological systems. This could lead to a better understanding of the mechanisms underlying radiation-induced damage and the development of more effective radioprotective agents in the future.

InChI:InChI=1/C4H10N2S.BrH/c1-2-3-7-4(5)6;/h2-3H2,1H3,(H3,5,6);1H

Upstream product

• 106-94-5 propyl bromide 
• 17356-08-0 thiourea 

Downstream Products

• 6898-84-6 sodium 1-propanethiolate 
• 20600-60-6 propylsulfanyl-acetic acid 

Relevant academic research and scientific papers

EFFECT OF VICINAL SUBSTITUENTS ON THE REACTIVITY IN BIMOLECULAR NUCLEOPHILIC SUBSTITUTION AT A SATURATED CARBON ATOM. TWO TYPES OF SUBSTITUENTS II. KINETICS OF THE REACTION OF THIOUREA WITH β-SUBSTITUTED BROMOETHANES IN ETHANOL

The kinetics of the reaction of thiourea with β-substituted bromoethanes in ethanol were studied by radiochromatography.The rate constants and activation parameters of the reactions were determined.It was shown that an isokinetic relationship is observed for the two types of substituents.The mechanisms of the effect of the vicinal substituents on the reactivity are discussed.

EFFECT OF VICINAL SUBSTITUENTS ON REACTIVITY IN BIMOLECULAR NUCLEOPHILIC SUBSTITUTION AT A SATURATED CARBON ATOM. TWO TYPES OF SUBSTITUENT I. KINETICS OF THE REACTIONS OF THIOUREA WITH β-SUBSTITUTED BROMOETHANES IN DIMETHYLFORMAMIDE

The kinetics of the reaction of thiourea with β-substituted bromoethanes in DMFA were studied by radiochromatography.It was shown that there is no isokinetic relationship or Taft equation for all the substituents but that there are isokinetic relationships for two separate reaction series, one of which is described satisfactorily by a Taft equation taking account of the inductive and steric effects of the substituents.On the basis of the obtained data it is supposed that there are two types of vicinal substituents, which affect the reactivity of the bromine at the saturated carbon atom by different mechanisms.For the first type of substituent (H, F, Br, CH3, C6H5) the main factors determining the reactivity are the inductive and steric effects of the substituents.Substituents of the second type (COOH, COOC2H5, CN, NH3Br, SC(NH2)2Br) include charged or highly polar substituents, and this makes it possible to expect a field effect, leading to additional stabilization of the transition state.

SYNTHESIS OF MONO(ALKYLTHIO)-SUBSTITUTED KETONES

In the reaction of 2-propanone in the presence of sodium bicarbonate with a mixture of formaldehyde and the corresponding alkaline hydrolyzates of S-alkylthiuronium salts (thioalcoholates) β-keto sulfides (1-alkylthio-3-butanones) were obtained.Ketalization of the products with glycerol gave the cyclic derivatives alkylthio-1,3-dioxolanes.