107100-47-0Relevant academic research and scientific papers
β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders
Vaidergorn, Miguel M.,Carneiro, Zumira A.,Lopes, Carla D.,de Albuquerque, Sérgio,Reis, Felipe C.C.,Nikolaou, Sofia,Mello, Juliana F.R. e,Genesi, Giovani L.,Trossini, Gustavo H.G.,Ganesan,Emery, Flavio S.
, p. 657 - 664 (2018)
It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and the
