107112-44-7Relevant academic research and scientific papers
Efficient synthesis of substituted pyrroles through Pd(OCOCF3)2-catalyzed reaction of 5-hexen-2-one with primary amines
Chen, Xi,Yang, Meng,Zhou, Min
, p. 5215 - 5218 (2016)
An efficient and facile Pd(OCOCF3)2-catalyzed one-pot cascade protocol has been developed for the synthesis of multiple substituted pyrroles in good to excellent yields. Unlike the reported method starting from the 2-alkenal-1,3-carbonyl compounds, the process utilizes the less reactive 5-hexen-2-one and the method has great potential as a complement to the current developed methods.
AN H-1, C-13 AND N-15 NMR STUDY OF THE PAAL-KNORR CONDENSATION OF ACETONYLACETONE WITH PRIMARY AMINES
Katritzky, Alan R.,Yousaf, Taher I.,Chen, Ban Chi,Guang-Zhi, Zeng
, p. 623 - 628 (2007/10/02)
The reaction of primary amines with acetonylacetone is shown by H-1, C-13 and N-15 NMR spectroscopy to proceed to the N-substituted -2,5-dimethylpyrroles via the intermediacy of N-substituted imines.Increased steric hindrance reduces rates of imine formation and decay.
