107125-71-3Relevant academic research and scientific papers
REACTIONS OF αω-BIS(BROMOMAGNESIO)ALKANES WITH HETEROCYCLIC ANHYDRIDES. A NOVEL SYNTHESIS OF FIVE AND SIX-MEMBERED 1-(o-AMINOPHENYL)CYCLOALKANOLS AND 1-(2'-AMINO-3'-PYRIDINYL)CYCLOALKANOLS
Canonne, P.,Boulanger, R.,Chantegrel, B.
, p. 663 - 668 (2007/10/02)
Isatoic anhydrides and azaisatoic anhydrides are converted by reaction with 1,4-bis(bromomagnesio)butane and 1,5-bis(bromomagnesio)pentane into the corresponding 1-(o-aminophenyl)cycloalkanols and 1-(2'-amino-3'pyridinyl)cycloalcanols.
Carbon Dioxide: A Reagent for the Simultaneous Protection of Nucleophilic Centres and the Activation of Alternative Locations to Electrophilic Attack. Prt III. A New Synthetic Method for the ortho-Substitution of N-Monoalkylanilines
Katritzky, Alan R.,Fan, Wei-Qiang,Akutagawa, Kunihiko
, p. 4027 - 4034 (2007/10/02)
N-Methyl- and N-ethyl-aniline are regiospecifically converted into a range of ortho-substituted derivatives, using carbon dioxide both for N-protection and as an intermediate carbanion stabilizing group, and t-butyllithium to lithiate the ortho-carbon atom.The rersulting lithium N-(ortho-substituted-phenyl)-N-methyl- and -N-ethylcarbamates undergo smooth acid-catalysed decarboxylation under mild conditions.No alpha-substituted products were detected.
