107134-59-8

Basic information

• Product Name: 7-DEAZA-DA CEP
• Synonyms: N6-BENZOYL-5'-O-(4,4'-DIMETHOXYTRITYL)-7-DEAZA-2'-DEOXYADENOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE;7-DEAZA-DA CEP
• CAS NO: 107134-59-8
• Molecular Formula: C48H53N6O7P
• Molecular Weight: 856.94
• Mol File: 107134-59-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-DEAZA-DA CEP(CAS DataBase Reference)
• NIST Chemistry Reference: 7-DEAZA-DA CEP(107134-59-8)
• EPA Substance Registry System: 7-DEAZA-DA CEP(107134-59-8)

Safety Data

• Hazardous Substances Data: 107134-59-8(Hazardous Substances Data)

Usage

General Description

7-DEAZA-DA CEP is a synthetic compound that belongs to the class of nucleoside analogues. It is a potent and selective inhibitor of adenosine deaminase (ADA), an enzyme that catalyzes the irreversible conversion of adenosine to inosine. By inhibiting ADA, 7-DEAZA-DA CEP can modulate the levels of adenosine in the body, which can have various effects on immune function and inflammatory responses. 7-DEAZA-DA CEP has been researched for its potential application in the treatment of autoimmune diseases, inflammation, and cancer due to its ability to regulate adenosine levels and modulate immune responses. Additionally, 7-DEAZA-DA CEP has shown promise as a potential therapeutic agent for neurodegenerative disorders, as adenosine dysregulation has been implicated in the pathogenesis of these conditions.

Upstream product

• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 90335-57-2 N-(7-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzamide 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant articles and documents

Chemically Stabilized DNA Barcodes for DNA-Encoded Chemistry

DNA-encoded compound libraries are a widely used small molecule screening technology. One important aim in library design is the coverage of chemical space through structurally diverse molecules. Yet, the chemical reactivity of native DNA barcodes limits the toolbox of reactions for library design. Substituting the chemically vulnerable purines by 7-deazaadenine, which exhibits tautomerization stability similar to natural adenine with respect to the formation of stable Watson–Crick pairs, yielded ligation-competent, amplifiable, and readable DNA barcodes for encoded chemistry with enhanced stability against protic acid- and metal ion-promoted depurination. The barcode stability allowed for straightforward translation of 16 exemplary reactions that included isocyanide multicomponent reactions, acid-promoted Pictet–Spengler and Biginelli reactions, and metal-promoted pyrazole syntheses on controlled pore glass-coupled barcodes for diverse DEL design. The Boc protective group of reaction products offered a convenient handle for encoded compound purification.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

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