1071436-36-6 Usage
General Description
(R)-3-P-TOLYL-BETA-ALANINOL, also known as (R)-3-(p-tolyl)alaninol or PTAL, is a chiral chemical compound with the molecular formula C10H13NO. It is a white to off-white solid that is used as a building block in the synthesis of various pharmaceuticals and other organic compounds. PTAL is classified as a beta-amino alcohol and is often used as a chiral auxiliary in asymmetric synthesis. It has a wide range of applications in the pharmaceutical and chemical industries due to its ability to influence the stereochemical outcome of reactions, making it an important tool for the production of enantiopure compounds. Additionally, PTAL has been studied for its potential biological activities and pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1071436-36-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,1,4,3 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1071436-36:
(9*1)+(8*0)+(7*7)+(6*1)+(5*4)+(4*3)+(3*6)+(2*3)+(1*6)=126
126 % 10 = 6
So 1071436-36-6 is a valid CAS Registry Number.
1071436-36-6Relevant articles and documents
Base-induced Sommelet–Hauser rearrangement of N-(α-(2-oxyethyl)branched)benzylic glycine ester-derived ammonium salts via a chelated intermediate
Baba, Souya,Hirano, Kazuki,Tayama, Eiji
supporting information, (2020/03/13)
The base-induced Sommelet–Hauser (S–H) rearrangement of N-(α-branched)benzylic glycine ester-derived ammonium salts 1 was investigated. When the α-branched substituent was a simple alkyl, such as a methyl or butyl, desired S–H rearrangement product 2 was obtained in low yield with formation of the [1,2] Stevens rearranged 4 and Hofmann eliminated products 5 and 6. However, when the α-branched substituent had a 2-oxy moiety, such as 2-acetoxyethyl or 2-benzoyloxyethyl, the yields of 2 were improved. These results could be explained by formation of chelated intermediate C that stabilizes the carbanionic ylide, and the subsequent initial dearomative [2,3] sigmatropic rearrangement would be accelerated. The existence of C was supported by mechanistic experiments. This enhancement effect is not very strong or effective; however, it will expand the synthetic usefulness of ammonium ylide rearrangements.
