1071476-83-9Relevant academic research and scientific papers
Structure optimization of a new class of PPARγ antagonists
Hernandez-Olmos, Victor,Knape, Tilo,Heering, Jan,von Knethen, Andreas,Kilu, Whitney,Kaiser, Astrid,Wurglics, Mario,Helmst?dter, Moritz,Merk, Daniel,Schubert-Zsilavecz, Manfred,Parnham, Michael J.,Steinhilber, Dieter,Proschak, Ewgenij
, (2019)
Peroxisome proliferator-activated receptor gamma (PPARγ) modulators have found wide application for the treatment of cancers, metabolic disorders and inflammatory diseases. Contrary to PPARγ agonists, PPARγ antagonists have been much less studied and alth
A Class of FeIII Macrocyclic Complexes with Alcohol Donor Groups as Effective T1 MRI Contrast Agents
Abozeid, Samira M.,Asik, Didar,Bateman, Gage,Burgio, Ariel,Morrow, Janet R.,Snyder, Eric M.,Spernyak, Joseph A.,Turowski, Steven G.
, p. 2414 - 2419 (2020)
Early studies suggested that FeIII complexes cannot compete with GdIII complexes as T1 MRI contrast agents. Now it is shown that one member of a class of high-spin macrocyclic FeIII complexes produces more intense contrast in mice kidneys and liver at 30 minutes post-injection than does a commercially used GdIII agent and also produces similar T1 relaxivity in serum phantoms at 4.7 T and 37 °C. Comparison of four different FeIII macrocyclic complexes elucidates the factors that contribute to relaxivity in vivo including solution speciation. Variable-temperature 17O NMR studies suggest that none of the complexes has a single, integral inner-sphere water that exchanges rapidly on the NMR timescale. MRI studies in mice show large in vivo differences of three of the FeIII complexes that correspond, in part, to their r1 relaxivity in phantoms. Changes in overall charge of the complex modulate contrast enhancement, especially of the kidneys.
COMPOUNDS FOR USE AS IRON (III) MRI CONTRAST AGENTS CONTAINING ANIONIC PENDENTS AND ANCILLARY GROUPS
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Paragraph 0120, (2020/06/05)
Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S- substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(III) atom coordinated to the TACN moiety. The macrocyclic complexes can be used in imaging methods.
Trapping of azidocarbenium ion: A unique route for azide synthesis
Pramanik, Suman,Ghorai, Prasanta
supporting information, p. 2104 - 2107 (2014/05/06)
For the first time, a sensitive azidocarbenium ion intermediate has been trapped with various nucleophiles to provide azides in excellent chemoselectivity. This provides a novel approach for the chemoselective synthesis of primary and secondary benzyl azides from aldehydes in a one-pot reaction. Enantioselective nucleophilic addition to the azidocarbenium ion has also been initiated.
