1071478-70-0Relevant articles and documents
Combination of RCM and the Pauson-Khand reaction: One-step synthesis of tricyclic structures
Rosillo, Marta,Arnaiz, Eduardo,Abdi, Delbrin,Blanco-Urgoiti, Jaime,Dominguez, Gema,Perez-Castells, Javier
, p. 3917 - 3927 (2008)
The combination of ring-closing metathesis (RCM) followed by an intramolecular Pauson-Khand reaction gives direct entry to tricyclic compounds. The RCM was carried out on a hexacarbonylcobalt-complexed alkyne, this complex acting as a protecting group against enyne metathesis. The procedure was studied for dienynes containing heteroatoms and allows the building of [6,5,5] and [7,5,5] tricyclic systems. The feasibility of the process depends strongly on the nature of the substrate. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.