107149-43-9Relevant academic research and scientific papers
Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents
Peters, Richard H.,Crowe, David F.,Tanabe, Masato,Avery, Mitchell A.,Chong, Wesley K. M.
, p. 646 - 652 (2007/10/02)
A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.
