107182-50-3Relevant academic research and scientific papers
The Catalyst-Controlled Divergent Cascade Reactions of Homo-Propargylic Amines and Nitrones: Synthesis of Pyrrolo-Isoxazolidines and γ-Lactams
Kong, Yuanfang,Liu, Yingze,Wang, Boyi,Li, Shengli,Liu, Lingyan,Chang, Weixing,Li, Jing
, p. 1240 - 1252 (2018)
Two controllable one-pot cascade cyclization reactions of homopropargylic amines and nitrones were developed by using different metal Cu and Ag salts. The pyrroloisoxazolidines and γ-lactams were obtained in good to high yields, respectively. Herein, nitr
Reductive Amination/Cyclization of Keto Acids Using a Hydrosilane for Selective Production of Lactams versus Cyclic Amines by Switching of the Indium Catalyst
Ogiwara, Yohei,Uchiyama, Takuya,Sakai, Norio
supporting information, p. 1864 - 1867 (2016/02/03)
Described herein is that the catalytic construction of N-substituted five- and six-membered lactams from keto acids with primary amines by reductive amination, using an indium/silane combination. This relatively benign and safe catalyst/reductant system tolerates the use of a variety of functional groups, especially ones that are reduction-sensitive. A direct switch from synthesizing lactams to synthesizing cyclic amines is achieved by changing the catalyst from In(OAc)3 to InI3. This conversion occurs by further reduction of the lactam using the indium/silane pair.
