1071838-87-3Relevant academic research and scientific papers
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and selective iGluR5 modulators
Butini, Stefania,Pickering, Darryl S.,Morelli, Elena,Coccone, Salvatore Sanna,Trotta, Francesco,De Angelis, Meri,Guarino, Egeria,Fiorini, Isabella,Campiani, Giuseppe,Novellino, Ettore,Schousboe, Arne,Christensen, Jeppe K.,Gemma, Sandra
supporting information; experimental part, p. 6614 - 6618 (2009/10/17)
(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.
