1071867-95-2Relevant academic research and scientific papers
A temporary-bridge strategy for enantioselective organocatalyzed synthesis of aza-seven-membered rings
Goudedranche, Sbastien,Pierrot, David,Constantieux, Thierry,Bonne, Damien,Rodriguez, Jean
, p. 15605 - 15608 (2015/01/08)
We report the first enantioselective organocatalyzed domino synthesis of azepane moieties. This temporary-bridge strategy is based on a conceptually original annulation of ambident electrophilic and 1,4-bis-nucleophilic α-ketoamides with 1,3-bis-electrophilic enals. The obtained oxygen-bridged azepanes can be selectively transformed into optically active azepanone, azepanol or azepanedione derivatives of high synthetic value. This journal is
