1071875-01-8Relevant academic research and scientific papers
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels
Yang, Zhi-Qiang,Barrow, James C.,Snipe, William D.,Schlegel, Kelly-Ann S.,Shu, Youheng,Yang, F. Vivien,Lindsley, Craig W.,Rittle, Kenneth E.,Bock, Mark G.,Hartman, George D.,Uebele, Victor N.,Nuss, Cindy E.,Fox, Steve V.,Kraus, Richard L.,Doran, Scott M.,Connolly, Thomas M.,Tang, Cuyue,Ballard, Jeanine E.,Kuo, Yuhsin,Adarayan, Emily D.,Prueksaritanont, Thomayant,Zrada, Matthew M.,Marino, Michael J.,Graufelds, Valerie Kuzmick,DiLella, Anthony G.,Reynolds, Ian J.,Vargas, Hugo M.,Bunting, Patricia B.,Woltmann, Richard F.,Magee, Michael M.,Koblan, Kenneth S.,Renger, John J.
supporting information; experimental part, p. 6471 - 6477 (2009/10/23)
The discovery of a novel series of potent and selective T-type calcium channel antagonists is reported. Initial optimization of high-throughput screening leads afforded a 1,4-substituted piperidine amide 6 with good potency and limited selectivity over hE
