1071907-28-2

Basic information

• Product Name: 4-hydroxybenzyl-H-phosphinic acid butyl ester
• CAS NO: 1071907-28-2
• Molecular Weight: 228.228
• Mol File: 1071907-28-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-hydroxybenzyl-H-phosphinic acid butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxybenzyl-H-phosphinic acid butyl ester(1071907-28-2)
• EPA Substance Registry System: 4-hydroxybenzyl-H-phosphinic acid butyl ester(1071907-28-2)

Safety Data

• Hazardous Substances Data: 1071907-28-2(Hazardous Substances Data)

Upstream product

• 4766-57-8 tetra(n-butoxy)silane 

Relevant articles and documents

Green, palladium-catalyzed synthesis of benzylic H-phosphinates from hypophosphorous acid and benzylic alcohols

Benzylic alcohols cross-couple directly with concentrated H 3PO2 by using Pd/xantphos (1 or 2 mol-%). Depending on the substrate, DMF at 110 °C or t-AmOH at reflux with a Dean-Stark trap can be used. A broad range of benzylic alcohols react successfully to give moderate to good yields of the products. The preparation of other organophosphorus compounds (phosphinic and phosphonic acids) is also demonstrated. Asymmetric reaction with (R)-1-(2-naphthyl)-ethanol provids the corresponding H-phosphinic acid in 77% ee. The methodology provides a green, PCl3-free route to benzylic-H-phosphinic acids. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.