1071918-67-6

Basic information

• Product Name: 2,2'-((5,5'-diselanediyl-bis(2-hydroxybenzoyl))-bis(azanediyl))diacetic acid
• Synonyms: 2,2'-((5,5'-diselanediyl-bis(2-hydroxybenzoyl))-bis(azanediyl))diacetic acid
• CAS NO: 1071918-67-6
• Molecular Weight: 546.254
• Mol File: 1071918-67-6.mol

Chemical Properties

• CAS DataBase Reference: 2,2'-((5,5'-diselanediyl-bis(2-hydroxybenzoyl))-bis(azanediyl))diacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-((5,5'-diselanediyl-bis(2-hydroxybenzoyl))-bis(azanediyl))diacetic acid(1071918-67-6)
• EPA Substance Registry System: 2,2'-((5,5'-diselanediyl-bis(2-hydroxybenzoyl))-bis(azanediyl))diacetic acid(1071918-67-6)

Safety Data

• Hazardous Substances Data: 1071918-67-6(Hazardous Substances Data)

Upstream product

• 1071918-62-1 C₁₈H₁₆N₂O₁₁Se₂ 
• 70-18-8 GLUTATHIONE 

Relevant articles and documents

Hydrophobicity and glutathione peroxidase-like activity of substituted salicyloyl-5-seleninic acids: Re-investigations on aromatic selenium compounds based on their hydrophobicity

Previously we have shown that some of 5-selenized salicylic acid derivatives exhibit glutathione peroxidase (GPx)-like activities higher than or equal to ebselen [Yu et al., Chem. Eur. J., 2008, 14, 7066; Org. Biomol. Chem., 2010, 8, 828]. For understandi

Synthesis of a new seleninic acid anhydride and mechanistic studies into its glutathione peroxidase activity

Starting from low toxic salicyloylglycine, a new seleninic acid anhydride 7 that lacks Se...N or Se...O non-bonded interactions was synthesized. This compound exhibits a four-fold higher glutathione peroxidase-like (GPx-like) activity than ebselen and inhibits plant and mammalian 12/15-lipoxygenases at lower micromolar concentrations. Because of these pharmacological properties, 7 may constitute a new lead compound for the development of anti-inflammatory low-molecular-weight seleno-organic compounds. Analyzing the redox products of 7 with glutathione (GSH) and tBuOOH, we identified three potential catalytic cycles (A, B, C) of GPx-like activity that are interconnected by key metabolites. To study the relative contribution of these cycles to the catalytic activity, we prepared selected reaction intermediates and found that the activity of seleninic acid anhydride 7 and of the corresponding diselenide 11 and selenol 14 compounds were in the same range. In contrast, the GPx-like activity of monoselenide 9 was more than one order of magnitude lower. These data suggested that cycles A and B may constitute the major routes of GPx-like activity of 7, whereas cycle C may not significantly contribute to catalysis.